Etusivulle

Muscarinic receptors2,3

Muscarinic receptors M12,3 +
  • In the central nervous system (cortex, hippocampus, neostriatum), half of the muscarinic receptors in the central nervous system are M1 receptors
  • In salivary glands, in sympathetic nerve ganglia
  • Blocking the function of the M1 receptor can cause a decrease in cognitive functions, confusion (delirium) and dry mouth
Muscarinic receptors M22,3 +
  • Throughout the central nervous system
  • In smooth muscle, heart muscle, detrusor muscle
  • Blocking the function of the M2 receptor can cause a decrease in cognitive functions, confusion (delirium), constipation, urinary retention and dry mouth
Muscarinic receptors M32,3 +
  • Small amounts throughout the central nervous system
  • In smooth muscle, eyes, salivary glands, detrusor muscle
  • Blocking of the function of the M3 receptor can cause dry mouth, constipation, urinary retention and blurred vision
Muscarinic receptors M42,3 +
  • In the central nervous system (neostriatum, cerebral cortex, hippocampus)
  • In the salivary glands
  • Blocking the function of the M4 receptor can cause a decrease in cognitive functions, confusion (delirium), dry mouth

 

Muscarinic receptors M52,3 +
  • In the central nervous system (substantia nigra, hippocampus)
  • In the eyes (ciliary body)
  • Blocking the function of the M5 receptor can cause blurred vision
Previous References

2. Kay GG, Abou-Donia MB, Messer WS Jr, Murphy DG, Tsao JW, Ouslander JG. Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients.J Am Geriatr Soc 2005;53:2195-201.

3. Karimi S, Dharia SP, Flora DS, Slattum PW. Anticholinergic burden: clinical implications for seniors and strategies for clinicians. Consult Pharm 2012;27:564-82.